Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

HeLa cells treated and untreated with Clinacanthus nutans DCM fraction

ABSTRACT: To investigate the effects of C. nutans DCM fraction on HeLa cells using transcriptomic analysis. We then performed gene expression profiling analysis using data obtained from RNA-seq of two different condition at two replicates.

ORGANISM(S): Homo sapiens

PROVIDER: GSE207454 | GEO | 2022/07/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

HeLa cells treated and untreated with Clinacanthus nutans DCM fraction

Project description:HeLa cells treated and untreated with Clinacanthus nutans DCM fraction

| PRJNA855643 | ENA

Subcellular distribution of RNAs in HeLa cells

Project description:HeLa cells were fractioned in nucleus and cytoplasm to investigate the subcellular distribution of lncRNAs. Two-condition experiment, nuclear fraction vs. cytoplasmatic fraction from HeLa cells. Biological replicates: 2 with dye-swap

2015-06-30 | E-GEOD-62985 | biostudies-arrayexpress

DCM-degrading enrichment culture

Project description:DCM consortia Raw sequence reads

| PRJNA347526 | ENA

Untreated vs. Camptothecin Treated HeLa cells

Project description:Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin. The response of tumor cells to the unusual form of DNA damage caused by topoisomerase poisons such as camptothecin (CPT) is poorly understood, and knowledge regarding which drugs can be effectively combined with CPT is lacking. To better understand the response of tumor cells to CPT and to identify potential targets for adjuvant therapy, we examined global changes in mRNA abundance in HeLa cells after CPT treatment using Affymetrix U133A GeneChips, which include all annotated human genes (22,283 probe sets). Statistical analysis of the data using a Bayesian/Cyber t test and a modified Benjamini and Hochberg correction for multiple hypotheses testing identified 188 probe sets that are induced and 495 that are repressed 8 h after CPT treatment at a False Discovery Rate of <0.05 and a minimum 3-fold change. This pharmacogenomic approach led us to identify two pathways that are CPT induced: (a) the epidermal growth factor receptor; and (b) nuclear factor-kappaB-regulated antiapoptotic factors. Experiments using HeLa cells in our lab and prior animal model studies performed elsewhere confirm that inhibitors of these respective pathways super-additively enhance CPT's cytotoxicity, suggesting their potential as targets for adjuvant therapy with CPT. Cancer Res. 2004 Mar 15;64(6):2096-104 Keywords = HeLa Keywords = Camptothecin Keywords: ordered

2004-05-18 | GSE1417 | GEO

S. coelicolor, Control (untreated) Vs Ciprofloxacin treated

Project description:Transcriptional profiling of S. coelicolor comparing control untreated cells with ciprofloxacin treated cells. Two-condition experiment, Control Vs CIP treatment. Biological replicates: 3 control, One dye swap replicate.

2014-01-01 | GSE49788 | GEO

HeLa E2F1 ChIP-chip experiments

Project description:These are three biological replicates. HeLa cells were crosslinked on separate days. In each case, a matched total from the same crosslinking was produced in parallel. Amplicons were made from each and hybridized onto ENCODE region tiling arrays. Two color arrays were used; ChIP was red, Total was green. Keywords: ChIP-chip

2006-02-28 | GSE4306 | GEO

IgG control ChIP in HeLa cells

Project description:Control IgG ChIP vs matched total for HeLa cells. Three biological replicates. Keywords: ChIP-chip

2006-03-09 | GSE4338 | GEO

HeLa E2F1 ChIP on 24,000 Promoters

Project description:2 biological replicates (array 59066 and array 64695) of HeLa E2F1 ChIP vs matched Total DNA Keywords: ChIP

2006-03-03 | GSE4319 | GEO

ENCODE Transcript Mapping for Human HeLa Total RNA

Project description:Transcript Mapping on Affymetrix ENCODE arrays for 3 different biological replicates of HeLa Total RNA Keywords: other

2007-04-06 | GSE7467 | GEO

Transcriptome profiling of untreated and doxycycline-treated HeLa/TO-SmN

Project description:Purpose is to examine the effect of SmN expression to gene expression in HeLa