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Cell contractility drives mechanical memory of oral squamous cell carcinoma

ABSTRACT: To study if non-invasive oral squamous cell carcinoma (OSCC) cells can acquire mechanical memory from stiff matrix and investigate the role of cell contractility in that process, Cal27 were conditioned (for 5 days) either by matrix stiffness or by direct modulation of cell contractility and then replated to a new niche lack of sources for the cells to learn. Cal27 with different types of conditioning were categorized either "Learn" or "Don't Lean/Forget" based on the existence of mechanical memory. Comparative gene expression profiling was done between "Learn" vs. "Don't Learn/Forget" Cal27 groups by RNA sequencing

ORGANISM(S): Homo sapiens

PROVIDER: GSE207685 | GEO | 2023/04/07

REPOSITORIES: GEO

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Expression data from actomyosin contractility regulated genes

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Expression data from pulmonary arterial endothelial cells treated with siRNA control or siGLS in stiff or soft matrix

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Three-Dimensional Matrix Stiffness Modulates Mechanosensitive and Phenotypic Alterations in Oral Squamous Cell Carcinoma Spheroids

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