Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation

ABSTRACT: In early embryogenesis, the primitive streak (PrS) generates the mesendoderm and is essential for organogenesis. However, because the PrS is a minute and transient tissue, elucidating the mechanism of its formation had been challenging. We had identified ceramide metabolism to regulate PrS formation. We investigated how C2 ceramide, a cell-permeable form of ceramide, affects gene expression for PrS formation.

ORGANISM(S): Mus musculus

PROVIDER: GSE207850 | GEO | 2023/08/03

REPOSITORIES: GEO