Metabolic regulation by p53 prevents R-loop-associated genomic instability [ATAC-Seq]

ABSTRACT: To investigate the role of p53 in maintaining genome integrity we deleted p53 via doxycycline-inducible short hairpin (sh)RNA targeting p53 (KPshp53 cells), and we treat the cells with the DNA demethylating molecule 5-Aza-2′-deoxycytidine (AZA or dC)

ORGANISM(S): Mus musculus

PROVIDER: GSE207878 | GEO | 2022/08/24

REPOSITORIES: GEO