Restrained Wnt signaling pathway by enhanced EsGSK3β phosphorylation activity facilitates the infection of intracellular bacterium Spiroplasma and leads to neuropathic diseases in crustaceans

ABSTRACT: To determine how Wnt-β-catenin regulates the innate immune response in crab hemocytes, Esβ-catenin and EsGSK3β RNA interference de novo transcriptomic analysis was performed to identify the innate immune-related genes regulated by this pathway. Venn analysis of differentially transcribed genes from Esβ-catenin-dsRNA vs. GFP-dsRNA (significantly downregulated) and EsGSK3β-dsRNA vs. GFP-dsRNA (significantly upregulated) of the screening generated 434 candidates. KEGG enrichment analysis of those candidate genes showed that many innate immune-related genes belonged to the Toll and IMD signaling pathways.

ORGANISM(S): Eriocheir sinensis

PROVIDER: GSE207959 | GEO | 2022/07/16

REPOSITORIES: GEO