Triple therapy reduced metastasis in triple-negative breast cancer

ABSTRACT: Purpose: To understand the underlying mechanisms of oncolytic virus therapy in breast cancer. Methods: The primary tumors of 4T1 in BALB/C mice were extracted and analyzed by RNA-seq. Results: In consistent with previous studies, we found some anti-tumor factors were up-regulated. Interestingly, several immunosupressive genes were activited. Conclusion: Our study identified the intercellular and intercellular factors restricting the optimized oHSV efficacy and supported the rationally designed triple therapy for clinical translation.

ORGANISM(S): Mus musculus

PROVIDER: GSE207977 | GEO | 2025/07/12

REPOSITORIES: GEO