In vitro stimulation of mouse spleen cells by mouse urine

ABSTRACT: Urinary tract-associated lymphoid structures (UTLASs), tertiary lymphoid tissues, are formed in renal pelvis (RP) of humans and mice with chronic kidney disease. We found that UTALS development was accelerated by urine leakage from RP lumen to the parenchyma following dysfunction of transitional epithelium covering UTLASs. Thus, UTALS-forming cells were stimulated by urine including urinary bio active substances.

ORGANISM(S): Mus musculus

PROVIDER: GSE207999 | GEO | 2024/04/15

REPOSITORIES: GEO