R-loop associated G-quadruplexes reinforce CTCF interactions

ABSTRACT: We report that three-stranded R-loop structures facilitate CTCF binding genome-wide through the formation of G-quadruplex (G4) structures. Genome-wide assays of CTCF and R-loop formation under various treatment conditions reveal that R-loop removal and G4 stabilization can both alter CTCF occupancy, and these changes are associated with alterations in gene expression and chromatin organization.

ORGANISM(S): Mus musculus

PROVIDER: GSE208145 | GEO | 2023/06/26

REPOSITORIES: GEO