Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity [RNA-seq]

ABSTRACT: Comparative gene expression profiling analysis of RNA-seq data for HCT116 cells and its shSMC4.

ORGANISM(S): Homo sapiens

PROVIDER: GSE208203 | GEO | 2023/06/05

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity [ATAC-seq]

Project description:ATAC-seq for HCT116 cells and its shSMC4.

2022-07-17 | GSE208201 | GEO

The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity [CUT&TAG]

Project description:CUT-Tag for histone H4K12la in HCT116 cells and its shSMC4.

2022-07-17 | GSE208202 | GEO

The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity[scRNA-seq]

Project description:We used single-cell sequencing to detect tumor cell types in mouse subcutaneous MC38 colorectal cancer

2023-06-20 | GSE234240 | GEO

Colorectal cancer cells with Suppressed SMC4 display a diapause-like state showing slow proliferation and chemotherapy insensitivity

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-17 | GSE208204 | GEO

Colorectal cancer cells with Suppressed SMC4 display a diapause-like state showing slow proliferation and chemotherapy insensitivity

Project description:Colorectal cancer cells with Suppressed SMC4 display a diapause-like state showing slow proliferation and chemotherapy insensitivity

| PRJNA858775 | ENA

Colorectal cancer cells with Suppressed SMC4 display a diapause-like state showing slow proliferation and chemotherapy insensitivity [ATAC-seq]

Project description:Colorectal cancer cells with Suppressed SMC4 display a diapause-like state showing slow proliferation and chemotherapy insensitivity [ATAC-seq]

| PRJNA858781 | ENA

Colorectal cancer cells with Suppressed SMC4 display a diapause-like state showing slow proliferation and chemotherapy insensitivity [CUT&TAG]

Project description:Colorectal cancer cells with Suppressed SMC4 display a diapause-like state showing slow proliferation and chemotherapy insensitivity [CUT&TAG]

| PRJNA858782 | ENA

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy.

Project description: Not available

| S-EPMC8437243 | biostudies-literature

Colorectal cancer cells possess an equipotent capacity to enter a reversible diapause-like state to survive chemotherapy

Project description:Cancer cells enter a reversible drug tolerant persister (DTP) state to evade death from chemotherapies and targeted agents. It is increasingly appreciated that DTPs are an important driver of therapy failure and tumor relapse. We combined cellular barcoding and mathematical modeling in patient-derived colorectal cancer models to identify and characterize DTPs in response to chemotherapy. Barcode analysis revealed no loss in clonal complexity of tumors that entered the DTP state and recurred following treatment cessation. Our data fits a mathematical model where all cancer cells, and not a small subpopulation, possess an equipotent capacity to become DTPs. Mechanistically, we determined that DTPs display remarkable transcriptional and functional similarities to diapause, a reversible state of suspended embryonic development triggered by unfavorable environmental conditions. Our study provides insight into how cancer cells use a developmentally conserved mechanism to drive the DTP state pointing to novel therapeutic opportunities to target DTPs.

2021-01-07 | GSE145356 | GEO

Human colorectal cancer cell LC-MS/MS

Project description:Six non- and drug-resistant colorectal cancer cell lines were selected in this study, which were non-resistant cell lines: HCT116 and LoVo, four drug-resistant cell lines: HCT116-OxPt, HCT116-SN38, LoVo-OxPt, LoVo-SN38.Proteins extraced from three HCT116 related cell lines were labled and pooled together, and proteins from other three LoVo related cell lines were labled and pooled together.

2022-03-04 | PXD004070 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data