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Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults

ABSTRACT: We molecularly characterized a class of histologically aggressive childhood liver cancers and showed that these tumors are clinically aggressive and that their observed histological features are associated with underlying recurrent molecular features. We proposed a diagnostic algorithm to identify these cancers using a combination of histological and molecular features, and our analysis suggested that these cancers may benefit from specialized treatment strategies that may differ from treatment guidelines for hepatoblastomas and hepatocellular carcinomas.

ORGANISM(S): Homo sapiens

PROVIDER: GSE208217 | GEO | 2022/07/15

REPOSITORIES: GEO

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