Transcriptomics

Dataset Information

44

EGFR Isoforms and Gene Regulation in Human Endometrial Cancer Cells


ABSTRACT: Microarrays were used to analyze differential gene expression and to help determine the efficacy of Iressa (gefitinib), a tyrosine kinase inhibitor, on endometrial cancer cells. Type I Ishikawa H and type II Hec50co endometrial carcinoma cells both express EGFR and sEGFR, but differ markedly in their responsiveness to the EGFR inhibitor gefitinib. This difference is paralleled by differences in the expression of sEGFR and EGFR, as well as in their transcriptional response following treatment with either EGFor gefitinib. The small cluster of differently regulated genes reported here in these type I vs. type II endometrial cancer-derived cell lines may identify candidate biomarkers useful for predicting sensitivity to EGFR blockade. Overall design: Type I (Ishikawa H cells) and type II (Hec50co) derived endometrial carcinomas, were dosed with either EGF(epidermal growth factor) or Iressa (gefitinib) for 12 or 24 hours and gene expression was examined.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

ORGANISM(S): Homo sapiens  

SUBMITTER: Gavin Pickett 

PROVIDER: GSE20854 | GEO | 2010-03-13

SECONDARY ACCESSION(S): PRJNA124765

REPOSITORIES: GEO

Similar Datasets

2010-01-01 | S-EPMC2907331 | BioStudies
2010-03-23 | E-GEOD-20854 | ArrayExpress
1000-01-01 | S-EPMC3612022 | BioStudies
2017-01-01 | S-EPMC5362536 | BioStudies
2020-01-01 | S-EPMC7322878 | BioStudies
2016-01-01 | S-EPMC4739624 | BioStudies
1000-01-01 | S-EPMC3700732 | BioStudies
2016-01-01 | S-EPMC5008301 | BioStudies
2017-01-01 | S-EPMC5256996 | BioStudies
1000-01-01 | S-EPMC3767783 | BioStudies