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YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis [MeDIP-Seq]

ABSTRACT: We use m6A-seq to report the most comprehensive survey to date of mRNA in spermatogonial stem cells (SSCs) and neural stem cell-like cells (iNSCs)

ORGANISM(S): Mus musculus

PROVIDER: GSE208724 | GEO | 2025/07/21

REPOSITORIES: GEO

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YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis [ChIP-Seq]

Project description:We use ChIP-seq to report the most comprehensive survey to date of chromatin organization in spermatogonial stem cells (SSCs) and neural stem cell-like cells (iNSCs)

2025-07-21 | GSE208723 | GEO

YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-07-21 | GSE208726 | GEO

YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis [RNA-Seq]

Project description:The expression profile data was obtained by RNA-Seq data.

2025-07-21 | GSE208725 | GEO

YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis [MeDIP-Seq]

Project description:YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis [MeDIP-Seq]

| PRJNA860811 | ENA

YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis

Project description:YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis

| PRJNA860801 | ENA

YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis [ChIP-Seq]

Project description:YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis [ChIP-Seq]

| PRJNA860812 | ENA

YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis [RNA-Seq]

Project description:YTHDF1 phase separation triggers the fate transsition of spermatogonial stem cells by activating IκB-NFκB-CCND1 axis [RNA-Seq]

| PRJNA860810 | ENA

Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse Testis (MeDIP-seq)

Project description:Background: Spermatogonial stem cells (SSCs) sustain the process of steady-state spermatogenesis in the mammalian testis, which is critical to the ongoing production of sperm and male fertility. SSCs can both self-renew to perpetuate the SSC population, and give rise to progenitors to propel the spermatogenic differentiation pathway. SSCs are detectable as a small subpopulation of undifferentiated spermatogonia that demonstrate regenerative capacity in a transplantation assay, and can be selectively recovered on the basis of expression of an Id4-eGfp sortable marker transgene. Enriched populations of SSCs and progenitors display consistent differences in gene expression patterns suggesting they represent discrete spermatogonial subtypes. Results: Here we describe distinct spermatogonial subtype-specific epigenetic programming profiles associated with subtype-specific differential gene expression on the basis of genome-wide patterns of six different histone modifications, chromatin accessibility, and DNA methylation. We find that similarly expressed genes show no differences in epigenetic programming, whereas differentially expressed genes show distinct histone modification patterns as well as subtype-specific differences in patterns of distal intergenic low-methylated regions. Motif-enrichment analysis of differentially programmed elements predicts a set of transcription factors that may regulate this spermatogonial subtype-specific epigenetic programming, and gene-specific chromatin immunoprecipitation analyses confirm subtype-specific differences in binding of a subset of these factors to target genes. Conclusions: Taken together, these results indicate that SSCs and progenitors are discrete spermatogonial subtypes that appear to be differentially programmed to carry out mutually exclusive functions including self-renewal and maintenance of regenerative capacity in SSCs and lineage commitment and loss of regenerative capacity in progenitors.

2019-05-23 | GSE131654 | GEO

FGF2-regulated gene expression in cultured mouse spermatogonial stem cells

Project description:Transcriptional profiling of mouse spermatogonial stem cells (SSCs) comparing control untreated SSCs with SSCs with exogenous FGF2 withdrawn and FGFR inhibitor SU5402 supplemented (-F+S). Results provide insight into the mechanisms of FGF2-supported in vitro self-renewal of SSCs. Two-condition experiment, SSCs-F+S vs. SSCs. Biological replicates: 4 control replicates, 4 -F+S replicates.

2010-08-01 | E-GEOD-21294 | biostudies-arrayexpress

Multiomics Approach to Profiling Development of the Spermatogonial Stem Cell Niche Focused on Sertoli cell Maturation

Project description:Spermatogonial stem cells are the foundation of spermatogenesis and as such can serve as a tool for the treatment of infertility in prepubertal cancer survivors. Spermatogonial stem cells are unique as they develop from primordial germ cells (PGCs), which colonize the developing tubules as immature SSC precursors. It has been controversial, when SSCs are maturing to an adult-like stem cell and recent research has found that prepubertal SSCs are actually metabolically distinct from adult SSCs until puberty. Sertoli cells picture a major part of the SSC niche and undergo drastic changes with puberty and polarize to compartmentalize the seminiferous epithelium with formation of tight junctions to a tight basal part where SSCs reside and an apical part with more differentiated stages of spermatogenesis. In the study were mapping the progression of Sertoli cells maturation events to the metabolic changes SSCs undergo during prepubertal development.

2023-02-24 | PXD037764 | Pride

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