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The dural innate immune barrier protects the CNS from systemic virus invasion [MHCII_10X]

ABSTRACT: To investigate heterogeneity of MHCII high CNS border-associated mononuclear phagocytes (BAMPs), MHCII high BAMPs from 30 adult male mice were FACS sorted and single-cell RNA seqs were performed

ORGANISM(S): Mus musculus

PROVIDER: GSE209574 | GEO | 2022/07/25

REPOSITORIES: GEO

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The dural innate immune barrier protects the CNS from systemic virus invasion [EC_10X]

Project description:To investigate heterogeneity of CNS border vasculatures, endothelial cells (EC) from 30 adult male mice were FACS sorted and single-cell RNA seqs were performed

2022-07-25 | GSE209573 | GEO

The dural innate immune barrier protects the CNS from systemic virus invasion [CD45_10X]

Project description:To investigate cellular landscape of dural immune cells, dural immune cells from 30 P28 male mice and 30 P7 male mice were FACS sorted and single-cell RNA seqs were performed

2022-07-25 | GSE209571 | GEO

The dural innate immune barrier protects the CNS from systemic virus invasion

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-25 | GSE209575 | GEO

Gene expression profile of GM-CSF derived bone marrow dendritic cell subsets

Project description:GM-CSF derived bone marrow cultures contain several subsets of CD11c+MHCII+ mononuclear phagocytes Using Affymetrix microarrays we compared gene expression of the different mononuclear phagocytes within the bone marrow culture The Affymetrix GeneChip Mouse Gene 1.0 arrays were used to define gene expression profiles in the different population.

2015-02-27 | E-GEOD-62361 | biostudies-arrayexpress

Gene expression profile of GM-CSF derived bone marrow dendritic cell subsets

2015-02-27 | GSE62361 | GEO

Gene expression profile of GM-CSF derived bone marrow dendritic cell subsets after LPS stimulation

Project description:GM-CSF derived bone marrow cultures contain several subsets of CD11c+MHCII+ mononuclear phagocytes Using Affymetrix microarrays we compared gene expression of the different mononuclear phagocytes within the bone marrow culture. The different populations are left unstimulated or are stimulated with LPS The Affymetrix GeneChip Mouse Gene 1.0 arrays were used to define gene expression profiles in the different population.

2015-09-01 | E-GEOD-62746 | biostudies-arrayexpress

Gene expression profile of GM-CSF derived bone marrow dendritic cell subsets after LPS stimulation

Project description:GM-CSF derived bone marrow cultures contain several subsets of CD11c+MHCII+ mononuclear phagocytes Using Affymetrix microarrays we compared gene expression of the different mononuclear phagocytes within the bone marrow culture. The different populations are left unstimulated or are stimulated with LPS

2015-09-01 | GSE62746 | GEO

IL-22 promotes postnatal formation of MUC17 glycocalyx barrier that protects host enterocytes

Project description:The apical aspects of absorptive epithelial cells form a highly organized brush border membrane (BBM), shaped by densely packed microvilli that are coated with a glycocalyx. Here, we present evidence showing that the glycocalyx forms an epithelial barrier that prevents exogenous molecules from gaining access to the BBM. We used a multiomics approach to investigate function and regulation of membrane mucins exposed on the enterocytic BBM during postnatal development of the small intestine. Muc17 was identified as a major membrane mucinin the glycocalyx that was specifically upregulated by IL-22 as part of an epithelial defense repertoire during suckling-weaning transition. High levels of IL-22 at the time of weaning primed progenitor enterocyte to express Muc17 as they migrate out of intestinal crypts to replace neonatal enterocytes. Our findings propose a role for membrane mucin Muc17 in epithelial barrier function in the small intestine.

2021-02-16 | PXD018592 | Pride

Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption.

Project description: Not available

| S-EPMC5491531 | biostudies-literature

Peyer's Patch BCR repertoire analysis in mice lacking H2-Ab1 on intestinal epithelial cells

Project description:Intestinal epithelial cells (IEC) express large amounts of major histocompatibility complex II (MHCII) molecules. Despite this long-appreciated observation, the function of epithelial MHCII-mediated signaling on gut homeostasis remains enigmatic. As IECs serve as the primary cellular barrier between intestinal microbes and underlying host immune cells, we reasoned that IEC-intrinsic antigen presentation may play a role in tolerogenic responses towards the microbiota. Mice with an IEC-intrinsic defect in MHCII expression (IECΔMHCII) develop elevated T cell-dependent IgA responses, but a reduction in microbiota responsive regulatory T cells (Tregs). Despite elevated IgA levels in IECΔMHCII mice, immunoglobulin repertoires exhibit less selection and IgA has reduced reactivity to the microbiota, which is associated with increased inter-individual variability in microbiota composition. Consistent with reductions in microbiota-responsive Tregs, IECΔMHCII mice develop worsened colitis. A striking difference observed in the absence of IEC-MHCII is that while transcription of MHCII is similar, underlying mononuclear phagocytes had reduced surface MHCII. Macrophages were found to be capable of acquiring MHCII molecules from IECs, and macrophages isolated from IECΔMHCII mice had decreased capacity to stimulate Treg development. Thus, epithelial-myeloid interactions govern development of adaptive responses to microbial antigens within the gastrointestinal tract.

2021-09-09 | GSE183711 | GEO

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