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Hallmarks of CD8 T cell dysfunction are established within hours of tumor antigen encounter prior to cell division

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE209712 | GEO | 2023/07/10

REPOSITORIES: GEO

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Hallmarks of CD8 T cell dysfunction are established within hours of tumor antigen encounter

Project description:RNA-SEQ analysis of antigen-specific CD8 T cells sorted from murine liver tumors and from the spleens of Listeria-infected mice at different early timepoints following adoptive transfer. We sequenced naive antigen-specific CD8 T cells from spleens for comparison.

2023-07-10 | GSE209711 | GEO

Hallmarks of CD8 T cell dysfunction are established within hours of tumor antigen encounter

Project description:ATAC-SEQ analysis of antigen-specific CD8 T cells sorted from murine liver tumors and from the spleens of Listeria-infected mice at different early timepoints following adoptive transfer. We sequenced naive antigen-specific CD8 T cells from spleens for comparison. We also sorted tumor-infiltrating antigen-specific CD8 T cells that were removed from tumors and parked in tumor-free hosts for 5 days. The overall goal of this study was to determine the earliest chromatin remodeling events in CD8 T cells activated and differentiating in late tumor-bearing hosts or in infected mice and to determine the extent to which tumor-induced chromatin remodeling was "imprinted."

2023-07-10 | GSE209710 | GEO