Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape

ABSTRACT: To understand ISR signaling we engineered photo-switchable control over the ISR stress sensor kinase PKR (opto-PKR), which allows virtual control of the ISR. Using controlled light inputs to activate opto-PKR we traced information flow in the ISR both globally, in the transcriptome, and for key ISR effectors

ORGANISM(S): Homo sapiens

PROVIDER: GSE210019 | GEO | 2022/07/31

REPOSITORIES: GEO