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Identification of GP33-specific CD8 T cell clones responding to chronic infection with LCMV-Clone13

ABSTRACT: T cells specific for a certain antigen are a heterogeneous population characterized by cells expressing different T Cell Receptors (TCRs). As the TCR determines the avidity of a T cell clone for its cognate antigen, this feature has also a significant impact on the fate of such clone during antigenic challenge. In the context of chronic viral infection, T cells specific for the chronic virus differentiate into exhausted cells with limited functionality. We find that, in the process of exhaustion following infection with LCMV-Clone13, certain clones of CD8 T cells specific for the LCMV immunodominant epitope GP33 are enriched compared to others.

ORGANISM(S): Mus musculus

PROVIDER: GSE210116 | GEO | 2022/10/23

REPOSITORIES: GEO

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