Effect of neonatal right ventricular pressure overload on gene expression and regions of open chromatin during postnatal heart development

ABSTRACT: To investigate the effect of pressure overload (PO) during postnatal right ventricular (RV) development, we established the RV PO model by conducting pulmonary artery banding (PAB) surgery on neonatal Sprague-Dawley (SD) rats. We then performed gene expression and chromatin openness profiling analysis using data obtained from RNA-seq and ATAC-seq of RV free walls from PO and sham-operated rats at postnatal day 21 (P21).

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE210180 | GEO | 2024/05/17

REPOSITORIES: GEO