Genomics

Dataset Information

315

Integrative genomic profiling of human prostate cancer


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Agilent-014693 Human Genome CGH Microarray 244A (Feature number version)

SUBMITTER: Barry Stephen Taylor 

PROVIDER: GSE21032 | GEO | 2010-06-24

SECONDARY ACCESSION(S): PRJNA126455 GSE21034 GSE21035 GSE21036

REPOSITORIES: GEO

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Publications


Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in approximately 11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that impl  ...[more]

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