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TAF2 and MYC cooperate to promote hepatocellular carcinoma

ABSTRACT: In order to check the tumorigenic property of TAF2, either alone or in combination with MYC, we used Sleeping Beauty (SB) transposase-mediated somatic integration in combination with hydrodynamic tail vein injection (HTVI) technique in FVB mice. TAF2 alone did not induce tumor, MYC overexpression induced tumors at a variable levels, while both TAF2 and MYC overexpression resulted in profound development of HCC.

ORGANISM(S): Mus musculus

PROVIDER: GSE210485 | GEO | 2025/12/12

REPOSITORIES: GEO

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