Metabolic activity affects RPE fate during cell reprogramming

ABSTRACT: To investigate transcriptomic changes that facilitate the reprogramming of retinal pigment epithelium (RPE) cells to neural retina, chicken RPE explants were cultured for 24 or 48 hours in the presence or absence of the reprogramming factor FGF2. To further interrogate the metabolic requirements of reprogramming, RPE explants were additionally cultured in the presence of the pyruvate dehydrogenase kinase inhibitor dichloroacetate in the presence or absence of FGF2.

ORGANISM(S): Gallus gallus

PROVIDER: GSE210526 | GEO | 2024/07/26

REPOSITORIES: GEO