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ScRNA-seq of Gene-edited Porcine Kidneys Prior to Xenotransplantation into Cynomolgus Macaques

ABSTRACT: Succesful xenotransplantation of porcine kidneys into humans requires the ubiqutous expression of certain human transgenes. Modern transcriptomics now alllows gene expression to be measured at the per-cell level, which can provide important insights into the expression pattern of these life-sustaining transgenes in a complex organ such as the kidney. Analysis of this scRNA-seq data shows ubiquitous expression of transgenes in most major kidney cell populations which includes various subtypes of endothelial cells.

ORGANISM(S): Sus scrofa

PROVIDER: GSE210557 | GEO | 2023/04/21

REPOSITORIES: GEO

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Longitudinal RNA-seq of Gene-edited Porcine Kidneys in Cynomolgus Macaques

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Project description:This SuperSeries is composed of the SubSeries listed below.

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