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Genomic profiles of asbestos-induced mesothelioma developed in wild-type and BRCA1+/- SD rats

ABSTRACT: Intraperitoneal administration of crocidolite or chrysotile is an established method to induce peritoneal malignant mesothelioma(MM), which shares common genetic alterations to those in humans. We conducted high-resolution microarray comparative genomic hybridization mesothelioma tissues obtained from both wild-type and BRCA1+/- rats to evaluate the involvement of BRCA1 haploinsufficiency in carcinogenesis.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE210598 | GEO | 2022/12/23

REPOSITORIES: GEO

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