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A Role for IFITM3 in Regulating Fibrinogen Endocytosis and Platelet Reactivity in Non-Viral Sepsis

ABSTRACT: Platelets and megakaryocytes are critical players in immune responses. Recent reports suggest infection and inflammation alter the megakaryocyte and platelet transcriptome to induce altered platelet reactivity. We examined if non-viral sepsis induces differential platelet gene expression and reactivity. Non-viral sepsis significantly upregulated IFITM3, an interferon responsive gene that restricts viral replication

ORGANISM(S): Homo sapiens

PROVIDER: GSE210797 | GEO | 2022/12/01

REPOSITORIES: GEO

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