Maternal transcription factor TCF12 mediates fertilization and zygotic genome activation during early embryonic development

ABSTRACT: To investigate the physiological function of TCF12 in oocyte maturation and preimplantational development, we crossed Tcf12fl/fl mice with Gdf9-Cre mice to specifically delete Tcf12 from the primordial follicle stage. We then performed gene expression profiling analysis using data obtained from RNA-seq on Tcf12fl/fl and Tcf12fl/fl;Gdf9-Cre growing GV oocytes (gGO), fully grown GV oocytes (fGO), embryos at 2-cell and 4-cell stage.

ORGANISM(S): Mus musculus

PROVIDER: GSE211286 | GEO | 2022/08/17

REPOSITORIES: GEO