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The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE211338 | GEO | 2023/09/11

REPOSITORIES: GEO

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The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration [ChIP-seq]

Project description:Here, we demonstrated that the signal transducer and activator of transcription 1 (Stat1) is essential for Schwann cell (SC) differentiation. To identify genes directly targeted by Stat1, we performed chromatin immunoprecipitation sequencing (ChIP-Seq) in differentiating rat SCs.

2023-09-11 | GSE211337 | GEO

The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration [RNA-seq]

Project description:To investigate the potential mechanisms of Stat1 regulation of Schwann cell (SC) differentiation, we performed a RNA sequencing (RNA-seq) of SCs grown under differentiation conditions treated with Stat1-siRNA or with non-targeting negative control siRNA (Scramble).

2023-09-11 | GSE211336 | GEO