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Effect of bryostatin-1 on gene expression profile of Raji cells

ABSTRACT: To investigate bryostain's effect on Raji , we performed a whole-transcriptome RNA sequencing experiment for Raji cells treated with Bryostatin and established differntial expression profile comparing to raji treated with DMSO.

ORGANISM(S): Homo sapiens

PROVIDER: GSE211351 | GEO | 2022/08/19

REPOSITORIES: GEO

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Epigenetic changes of Raji Epstein–Barr viral genome in reponse to byrostatin treatment

Project description:We report the application of cut&tag technology for high-throughput profiling of histone modifications Raji Epstein–Barr viral genome in reponse to bryostatin treatment. Dual- and tri-methylation of lysine 4 on histone H3 protein indicate genes that are actively expressed/regulated. Tri-methylation of lysine 27 on histone H3 protein marks genes that are negatively regulated or suppressed for expression.

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Effect of overexpression of NCAL1 on gene expression profile of NK92MI cells

Project description:To investigate NCAL1 effect on NK92MI cells , we performed a whole-transcriptome RNA sequencing experiment for NK92MI cells overexpressing NCAL1 and established differntial expression profile comparing to control NK92MI cells.

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Genome-wide epigenetic changes of leukemia cell lines in reponse to byrostatin treatment

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Determine genes differentially expressed between Raji cells and a subline which is resistant to APTO-253 (Raji/253R)

Project description:To obtain further insight into the resistance mechanism, RNA-seq analysis was carried out on 3 independent samples of both the sensitive Raji and resistant Raji/253R cells. A gene-level differential expression analysis was performed by removing all genes with less than 50 reads across all 6 samples as genes with only low level expression can cause irregularities in differential expression analysis. Genes were considered to be differentially expressed if their adjusted p-value was less than the 0.05 level and their fold change was >2 in either direction. Among the 13,791 evaluable genes there were 1,012 that were significantly up-regulated in the Raji/253R cells and 704 genes that were significantly down regulated relative to the parental sensitive Raji cells. The ATP-binding cassette sub-family member ABCG2 was the most up-regulated gene with more than a thousand-fold increase in transcript level. Genes were considered to be differentially expressed if their adjusted p-value was less than the 0.05 level and their fold change was >2 in either direction.

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Gene expression assay from Raji human B cells

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Expression of the TM4SF member CD9 on the human Burkitts lymphoma cell line Raji

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Transcription profiling of human Burkitts lymphoma cells line Raji expressing the TM4SF member CD9

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Project description:Transcriptional profiling of Curcumin treated S. mansoni adult worms (15uM of Curcumin in DMSO during 24h) vs. Non-treated S.mansoni adult worms (DMSO during 24h)

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