Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Immune microenvironment and molecular mechanism of oral lichen planus [Single cell RNA-Seq]

ABSTRACT: Oral lichen planus (OLP) is a chronic inflammatory disease with various clinical subtypes. Recurrent erosion of OLP brings great physical and mental pain to patients without clear pathogenesis. Herein, this study is the first to utilize single-cell RNA sequencing combined with spatial transcriptome and bulk RNA-seq to explore the tissual microenvironments of patients within normal oral mucosa, non-erosive OLP (ENOLP) and erosive OLP (EOLP).

ORGANISM(S): Homo sapiens

PROVIDER: GSE211630 | GEO | 2022/08/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Immune microenvironment and molecular mechanism of oral lichen planus [bullk RNA-Seq]

Project description:Oral lichen planus (OLP) is a poorly understood chronic inflammatory mucocutaneous disease and is associated with many systemic diseases, which may lead to the erosion of oral mucosa and bring physical and psychological disorders to patients. However, the pathogenesis and immune microenvironment of OLP with different clinical subtypes are unclear. therefore, this study established a clinical cohort of OLP with 1-year follow-up and obtained the clinical information and bulk RNA-seq files to explore the immune microenvironment and molecular mechanism of oral lichen planus with different clinical subtypes. Based on the erosion of oral mucosa in the biopsy, the participants of OLP were divided into two groups, non-erosive OLP (NEOLP) and erosive OLP (EOLP). According to whether erosion occurred in oral mucosa more than three times and a remission period of less than 3 months within a one-year follow-up, OLP was divided into two groups, recalcitrant erosive OLP (REOLP) and stable OLP (SOLP).

2023-08-01 | GSE213346 | GEO

Immune microenvironment and molecular mechanism of oral lichen planus [Spatial transcriptomics]

Project description:Oral lichen planus (OLP) is a poorly understood chronic inflammatory mucocutaneous disease and is associated with many systemic diseases, which may lead to the erosion of oral mucosa and bring physical and psychological disorders to patients. However, the pathogenesis and immune microenvironment of OLP with different clinical subtypes are unclear. therefore, this study utilized single cell RNA-sequencing and spatial transcriptomics to explore the immune microenvironment and molecular mechanism of oral lichen planus with different clinical subtypes. Moreover, this study established a clinical cohort of OLP with 1-year follow-up and obtained the clinical information and bulk RNA-seq files to further confirm the above results.

2023-08-01 | GSE213345 | GEO

Expression profile of circular RNAs in oral lichen planus: a promising study of circRNA to explore the pathogenesis of oral lichen planus

Project description:Six oral mucous biopsies from untreated patients with oral lichen planus (OLP) and six normal oral mucous tissues from healthy patients were used for circRNA sequencing. 135 circRNAs with 2-fold differential expression were identified in OLP compared with normal control, including 83 upregulated circRNAs and 52 downregulated circRNAs. Ten selected circRNAs were validated by real-time qPCR

2022-05-21 | GSE131567 | GEO

Transcrpitomic analysis of Oral lichen planus with immumosuppressive therapy

Project description:We compared the transcriptomes of tissues from Oral lichen planus patients with immunosuppressive therapy to reveal the biological mechanism of oral lichen planus treatment.

2022-06-05 | GSE204663 | GEO

Gene expression profiling of oral and genital lichen planus epithelium and normal oral and genital epithelium

Project description:Comparing gene expression in Oral and genital lichen planus with normal oral and genital epithelium trying to idenitfy differently expressed genes in lichen planus compared to normal epithelium Total RNA obtained from oral and genital lichen planus epithelium compared with normal oral and genital epithelium

2013-11-08 | E-GEOD-52130 | biostudies-arrayexpress

Profiling of Salivary Exosomal microRNAs in Oral Lichen Planus Patients [set 2]

Project description:In this study, we compared microRNA (miRNA) profiles of salivary exosomes of patients with oral lichen planus with those of healthy controls. Saliva samples from 16 patients with oral lichen planus and 8 healthy controls were divided into 2 sets and were examined by performing miRNA microarray analysis. Examination of 8 oral lichen planus patients and 4 healthy controls. Each patient and control represent pooled RNAs from salivary exosomes of 8 patients and 4 healthy controls, respectively. Please note that each set (i.e. set1 and set2) was analysed independently.

2015-04-30 | E-GEOD-68407 | biostudies-arrayexpress

Profiling of Salivary Exosomal microRNAs in Oral Lichen Planus Patients [set 1]

2015-04-30 | E-GEOD-68406 | biostudies-arrayexpress

Gene expression profiling of oral and genital lichen planus epithelium and normal oral and genital epithelium

2013-11-08 | GSE52130 | GEO