Gene expression profiling of mir-1825 alteration in Head and neck squamous cell carcinomas

ABSTRACT: Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common malignant cancer worldwide. To understand the pathogenesis of HNSCC, we investigated the effects of miR-1825 overexpression on tumor formation capacity of head and neck cancer cells in vivo using NUDE mice. We searched for potential targets of miR-1828 using microarray analysis and luciferase assay. We found that miR-1825 expression is upregulated in head and neck cells and clinical tumor samples in comparison to corresponding controls, where it potentially acts as an oncogene.

ORGANISM(S): Homo sapiens

PROVIDER: GSE211921 | GEO | 2025/07/23

REPOSITORIES: GEO