Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Requirements for Establishment and Epigenetic Inheritance of Mammalian Heterochromatin

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE212155 | GEO | 2025/09/17

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Requirements for Establishment and Epigenetic Inheritance of Mammalian Heterochromatin [CRISPR Screen]

Project description:Heterochromatic domains of DNA account for a large fraction of mammalian genomes and have critical roles in silencing of transposons and genes but the mechanisms that establish and maintain these domains are not fully understood. Here we use an inducible heterochromatin formation system combined with targeted CRISPR gene disruption to show that DNA sequence-independent and histone H3 lysine 9 methylation (H3K9me)-dependent heterochromatin can only be inherited during a limited number of cell divisions in mouse embryonic stem cells but becomes stable upon differentiation. We show that multiple H3K9 methyltransferases work together with DNA cytosine methyltransferases and other factors, including RNA processing proteins, to establish and maintain heterochromatin. In addition, we find that deletion of DHX9, an RNA/DNA helicase, results in defective heterochromatin maintenance associated with R-loop accumulation. Our findings suggest that components of H3K9 and DNA methylation pathways work in concert to ensure heterochromatin stability which additionally requires R-loop removal.

2025-09-17 | GSE212152 | GEO

Requirements for Establishment and Epigenetic Inheritance of Mammalian Heterochromatin [ChIP-Seq]

Project description:Heterochromatic domains of DNA account for a large fraction of mammalian genomes and have critical roles in silencing of transposons and genes but the mechanisms that establish and maintain these domains are not fully understood. Here we use an inducible heterochromatin formation system combined with targeted CRISPR gene disruption to show that DNA sequence-independent and histone H3 lysine 9 methylation (H3K9me)-dependent heterochromatin can only be inherited during a limited number of cell divisions in mouse embryonic stem cells but becomes stable upon differentiation. We show that multiple H3K9 methyltransferases work together with DNA cytosine methyltransferases and other factors, including RNA processing proteins, to establish and maintain heterochromatin. Our findings suggest that components of H3K9 and DNA methylation pathways work in concert to ensure heterochromatin stability.

2025-09-17 | GSE212153 | GEO

Requirements for Establishment and Epigenetic Inheritance of Mammalian Heterochromatin

Project description:Requirements for Establishment and Epigenetic Inheritance of Mammalian Heterochromatin

| PRJNA874101 | ENA

RNAi mediates allele-specific epigenetic inheritance of heterochromatin

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-04-26 | GSE111859 | GEO

The INO80 complex regulates epigenetic inheritance of heterochromatin

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-18 | GSE150545 | GEO

Environmentally induced epigenetic transgenerational inheritance of ovarian disease

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-07-17 | E-GEOD-59278 | biostudies-arrayexpress

Specialized replication of heterochromatin domains ensures self-templated chromatin assembly and epigenetic inheritance

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-02-02 | GSE242431 | GEO

Nuclear peripheral positioning of heterochromatin by Amo1NUPL2 suppresses nucleosome turnover to promote epigenetic inheritance

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-01-11 | GSE132865 | GEO

Requirements for Establishment and Epigenetic Inheritance of Mammalian Heterochromatin [CRISPR Screen]

Project description:Requirements for Establishment and Epigenetic Inheritance of Mammalian Heterochromatin [CRISPR Screen]

| PRJNA874105 | ENA

Requirements for Establishment and Epigenetic Inheritance of Mammalian Heterochromatin [ChIP-Seq]

Project description:Requirements for Establishment and Epigenetic Inheritance of Mammalian Heterochromatin [ChIP-Seq]

| PRJNA874110 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data