Defining key transcriptional regulators of extravillous trophoblast differentiation [RNA-seq]

ABSTRACT: During early human pregnancy, extravillous trophoblasts (EVT) play a central role in placental anchorage and blood vessel remodeling. Despite the essential roles in pregnancy, key factors and mechanisms underlying EVT differentiation remain largely unknown. Here, we defined key transcription factors (TFs) by monitoring the dynamics of transcriptome and enhancer usage during EVT differentiation. We confirmed the requirements of the defined TFs and identified their action mechanisms.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212266 | GEO | 2024/01/16

REPOSITORIES: GEO