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The protective effects of exercise training on heart failure with preserved ejection fraction

ABSTRACT: Heart failure with preserved ejection fraction (HFpEF) is a serious health problem with limited treatment options. This study is designed to investigate the protective function of exercise training in regulating heart failure with preserved ejection fraction (HFpEF).

ORGANISM(S): Mus musculus

PROVIDER: GSE212839 | GEO | 2025/12/31

REPOSITORIES: GEO

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Chromatin Remodelers in Cardiometabolic Heart Failure with Preserved Ejection Fraction

Project description:Cardiometabolic heart failure with preserved ejection fraction (cHFpEF) is highly prevalent and associated with a poor outcome. Pathological gene expressions in heart failure are accompanied by changes in active histone marks without major alterations in DNA methylation. Whether chromatin modifications participate to obesity-induced HFpEF is largely unknown. We will investigate whether chromatin marks participate to obesity-induced HFpEF in vivo.

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Project description:To understand the cellular mechanisms of heart failure with preserved ejection fraction (HFpEF), We investigated the functional outcome and the underlying mechanisms from concurrent mechanic and metabolic stresses in the heart by applying transverse aortic constriction (TAC) in lean C57Bl/6J (HFrEF phenotype) or obese/diabetic B6.Cg-Lepob/J (ob/ob) mice (HFpEF phenotype) followed by single-nuclei RNA-seq (snRNA-seq) and targeted manipulation of a top ranked signaling pathway (glucagon receptor signaling) differentially affected in the two experimental cohorts.

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