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Wild type and Ppara KO, CL time course

ABSTRACT: Time course og gene expression changes in white fat of wildtype and Ppara KO mice during treatment with the adrb3 agonist CL 316,234. Keywords: time-course

ORGANISM(S): Mus musculus

PROVIDER: GSE2131 | GEO | 2005/06/10

SECONDARY ACCESSION(S): PRJNA91747

REPOSITORIES: GEO

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Transcription profiling of white adipose tissue from wild type and Ppara KO mice treated with the adrb3 agonist CL 316243 to understand the metabolic and cellular plasticity in the tissue.

Project description:Time course of gene expression changes in white fat of wildtype and Ppara KO mice during treatment with the adrb3 agonist CL 316243.

2007-09-21 | E-GEOD-2131 | biostudies-arrayexpress

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Project description:TIme course of gene expression changes in epididymal white adipose tissue of 3-4 month old male Bl6 mice treated with CL 316243 for 0,1,3 or 6 days Keywords: time-course

2005-06-10 | GSE2130 | GEO

Genome-wide profiling of PPARA in PPARA agonist-treated mouse livers [ChIP-seq]

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Mus musculus

Project description:Wild type and Ppara KO, CL time course

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Global hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice treated or not with Fenofibrate

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Global hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice treated or not with Fenofibrate

Project description:Fenofibrate is a specific agonist of the nuclear receptor PPARa. To identify the gene expression under the strict dependence of hepatic PPARa activity, we generated a new mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to total Ppara KO (KO), wild-type (WT) and liver WT (albumin-Cre-/- Pparaflox/flox or LWT) mice. We used microarrays to detail the global programme of gene expression in liver of Ppara LKO, LWT, Ppara KO and WT male mice. There are 36 liver samples, each from an individual mouse. The samples are from Ppara liver KO (LKO), Ppara KO (KO), wild-type (WT) and liver WT (LWT) male mice of 14 week-old from the same genetic background (C57Bl/6J) treated with Fenofibrate (100 mg/kg/day) or vehicle (aqueous solution of gum Arabic 3%) by daily gavage for 10 days. n= 4 mice for LKO, LWT and WT genotypes treated with vehicle; n=3 for KO mice treated with vehicle; n=5 mice for LWT, LKO and KO genotypes treated with fenofibrate; n=4 WT mice treated with fenofibrate. All mice were sacrified at ZT14.

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Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation

Project description:Peroxisome proliferator-activated receptor α (PPARA) is a key mediator of lipid metabolism and inflammation. Activation of PPARA in rodents causes hepatocyte proliferation, but the underlying mechanism is poorly understood. This study focused on genes repressed by PPARA and analyzed the mechanism by which PPARA promotes hepatocyte proliferation in mice. Activation of PPARA by agonist treatment was autoregulated, and induced expression of the epigenetic regulator UHRF1 via activation of the newly described PPARA target gene E2f8, that in turn regulates Uhrf1. UHRF1 strongly repressed expression of CDH1 via methylation of the Cdh1 promoter marked with H3K9me3. Repression of CDH1 by PPARA activation was reversed by PPARA deficiency or knockdown of E2F8 or UHRF1. Furthermore, forced expression of CDH1 inhibited expression of the Wnt signaling target genes such as Myc after PPARA activation, and suppressed hepatocyte hyperproliferation. These results demonstrate that the PPARA-E2F8-UHRF1-CDH1 axis causes epigenetic regulation of hepatocyte proliferation. This SuperSeries is composed of the SubSeries listed below.

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