Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

DNA methylome and gene expression profiling of paired primary cancer and liver metastasis from colorectal cancer patients

ABSTRACT: We generated reduced representation bisulfite sequencing (RRBS) and RNA sequencing (RNA-Seq) data of 20 samples (paired primary and liver metastases from 10 CRC patients) to understand key molecular events involved in tumor progression and metastasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE213402 | GEO | 2023/08/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Analysis of paired primary and metastatic cell lines identifies common DNA methylation changes in melanoma metastasis.

Project description:Using 1 melanocyte and 6 melanoma cell line (3 pair of primary and metastatic), we generated base-resolution DNA methylation maps to document DNA methylation drivers of melanoma metastasis. Here we generated single-nucleotide resoultion DNA methylation map of a total of 7 cell lines using Reduced Representation Bisulfite Sequencing (RRBS)

2017-05-17 | E-GEOD-70621 | biostudies-arrayexpress

The Myonuclear DNA Methylome in Response to an Acute Hypertrophic Stimulus

Project description:We conducted reduced representation bisulfite sequencing (RRBS) on myonuclei and interstitial nuclei and observed stark differences in methylation patterns during adaptation

2020-04-13 | GSE144774 | GEO

Murine mammary epithelial cell methylome and ATAC-seq analyses

Project description:The following data comes from two separate experiments. In the initial experiment, luminal and basal murine mammary epithelial cells were analyzed by reduced representation bisulfite sequencing (RRBS) to generate methylome profiles. In the second experiment, luminal and basal murine mammary epithelial cells were analyzed by ATAC-seq.

2018-06-10 | GSE80181 | GEO

Assessing the influence of DNMTi on human CD8+ T cells on a global level using methylome and transcriptome analyses.

Project description:RRBS (Reduced Representation Bisulfite Sequencing) and RNA-seq were performed on human CD8+ T cells from peripheral blood of three independent healthy donors to study the influence of DNMTi on CD8+ T cells on a global level.

2021-02-08 | GSE93383 | GEO

Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation

Project description:To assess variation and inheritance of genome-wide patterns of DNA methylation simultaneously in humans, we applied reduced representation bisulfite sequencing (RRBS) to somatic DNA from six members of a three-generation family. Reduced representation bisulfite sequencing was applied to genomic DNA from leukocytes of 6 family members and two unrelated individuals.

2011-07-01 | E-GEOD-30253 | biostudies-arrayexpress

Genes differentially methylated after DNA methyltransferase 1 (DNMT1) knockdown in the presence or absence of early osteoblast (OB) differentiation [RRBS]

Project description:reduced representation bisulfite sequencing (RRBS) sequencing was performed to analyze methylation profiles regulated by DNMT1 in C3H10T1/2 MSCs with or without OB differentiation.

2021-07-15 | GSE179903 | GEO

Genome-scale DNA methylation maps of mouse chromaffin cells with or without Sdhb knock-out.

Project description:We report the analysis of DNA methylation in mouse chromaffin cell lines using reduced representation bisulfite sequencing (RRBS). We compared DNA methylation profiles of cell lines with or without a knock-out of Sdhb gene, showing that Sdhb disruption results in a hypermethylator phenotype. Reduced representation bisulfite sequencing of 4 mouse chromaffin cell samples (2 Sdhb wild-type and 2 Sdhb knock-out).

2013-05-06 | E-GEOD-44350 | biostudies-arrayexpress

Genome-wide DNA methylation profiling of human dorsolateral prefrontal cortex

Project description:Reduced representation bisulfite sequencing (RRBS) was conducted on dorsolateral prefrontal cortex tissue samples taken from the brains of control individuals not affected by neurological disorder DNA methylation profiling was conducted using RRBS and the Illumina Genome Analyzer IIx

2012-11-29 | E-GEOD-42590 | biostudies-arrayexpress

Profiling the DNA methylation pattern in naïve induced Pluripotent Stem cells and somatic cells

Project description:We analysed by Reduced Representation Bisulfite Sequencing (RRBS) the genome methylation pattern in human fibroblast and in naïve induced pluripoent stem cells (niPSCs)

2018-12-31 | GSE110366 | GEO

Genome-wide DNA methylation profiling of human dorsolateral prefrontal cortex

2012-11-29 | GSE42590 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data