Prolonged sleep deprivation induces cytokine storm-like syndrome in mammals [scRNA-Seq]

ABSTRACT: Sleep is deeply involved in neuroimmune regulation, while the mechanism is yet to be elucidated. Experimental manipulation of sleep duration provides a reliable measure for evaluating how sleep regulates innate immunity. Here we report a modified sleep deprivation paradigm (SD) that can constantly awaken the mice with more than 95% efficiency, and investigate the effects of prolonged sleep deprivation on mice's immune systems.

ORGANISM(S): Mus musculus

PROVIDER: GSE213496 | GEO | 2023/11/27

REPOSITORIES: GEO