Transcriptomics

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P16 epimutation modulates the tumor microenvironment and promotes malignancy of Apc-mutant colon cancer (RNA-Seq)


ABSTRACT: Using a mouse model of engineered p16 promoter hypermethylation (p16cis/cis), we found that p16 epimutation cooperates with mutant Apc to promote colon cancer development. Therefore, we performed RNA-seq analysis to identify genes regulated by p16 epimutation that contribute to intestinal carcinogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE213566 | GEO | 2023/08/02

REPOSITORIES: GEO

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