Endogenous B cell TACI-Short-APRIL signaling

ABSTRACT: Here we show that TACI-S increases its expression with maturation and colocalizes in the intracellular compartment with the ligand APRIL. APRIL downregulation in human B cells, eliminated class switch. These studies suggest the importance of intracellular APRIL together with TACI-S in maintaining humoral immunity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE213981 | GEO | 2023/09/22

REPOSITORIES: GEO