Single-Nucleus Chromatin Accessibility Identifies a Critical Role for TWIST1 in IPF Myofibroblast Activity

ABSTRACT: Multiomic single-cell analyses on human IPF lungs identify a global opening of TWIST1 and other E-box motifs in IPF myofibroblasts, with in vivo murine models confirming a critical regulatory function for TWIST1 in IPF myofibroblast activity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE214085 | GEO | 2023/05/04

REPOSITORIES: GEO