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RNA-seq Analysis of Tgfbr2f/f and Tgfbr2HKO Mouse Liver Transcriptomes

ABSTRACT: Purpose: To identify the alterations of genes transcriptional profile of livers obtained from Tgfbr2f/f mice and Tgfbr2HKO mice treated with CCl4. Methods: we generated hepatocyte-specific Tgfbr2 knockout (Tgfbr2HKO) mice by AAV8-TBG-Cre injection via the tail vein of Tgfbr2f/f. Tgfbr2f/f mice and Tgfbr2HKO were intraperitoneally injected with 0.25 ml/kg CCl4 (diluted 1:3 (v/v) in olive oil) twice a week for 4 weeks to induce liver fibrosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE214119 | GEO | 2022/09/27

REPOSITORIES: GEO

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