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DNA methylation restricts default deterministic fates towards neural and germline lineages during early development

ABSTRACT: We investigate the impact of DNA methylation on chromatin accessibility during epiblast differentiation. To this end, we used in vitro Epiblast-like cell (EpiLC) differentiation on WT and DNA-methylation free TKO murine ESCs. We next performed ATAC seq using TDE1 Tn5 transposase (Nextera).

ORGANISM(S): Mus musculus

PROVIDER: GSE214458 | GEO | 2023/10/09

REPOSITORIES: GEO

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