Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

ABSTRACT: Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

ORGANISM(S): Homo sapiens

PROVIDER: GSE214569 | GEO | 2023/05/11

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Microencapsulated 3D co-cultures recapitulate phenotypic features of B lymphomas

Project description:Microencapsulated 3D co-cultures recapitulate phenotypic features of B lymphomas

| PRJNA741518 | ENA

Colon cancer

Project description:Colon cancer

| PRJNA300948 | ENA

Microencapsulated 3D co-cultures recapitulate phenotypic features of B lymphomas

Project description:Non-Hodgkin B-cell lymphomas (B-NHL) mainly develop within lymph nodes (LN) as densely packed aggregates of tumor cells and their surrounding microenvironment, creating a tumor niche specific to each lymphoma subtypes. In vitro preclinical models mimicking biomechanical forces, cellular microenvironment, and 3D organization of B-cell lymphomas remain scarce, while all these parameters constitute key determinants of lymphomagenesis and drug resistance. Using a microfluidic method based on cell encapsulation inside permeable, elastic, and hollow alginate microspheres, we developed a new tunable 3D-model incorporating lymphoma B cells, extracellular matrix and/or stromal cells.Using RNA-sequencing, we reported that, in contrast to classical 2D cocultures, our 3D lymphoma model initiated a coevolution of these two cell types, recapitulating the physiopathology of B lymphoma tissue.

2021-08-16 | GSE178935 | GEO

Single-cell RNA-sequencing of organoid derived from colon cancer stem cells

Project description:To identify the tumor heterogeneiety among a single organoid that recapitulate the human colon cancer tissues, we put a single organoid derived from single colon cancer stem cells into single-cell RNA-sequencing. Isolated single cells were processed with Fluidigm C1 Single Cell Auto Prep system. 71 cells and one bulk control were sequenced using HiSeq2500.

2021-03-01 | GSE140897 | GEO

Human MSI colon cancer

Project description:Human MSI colon cancer

| PRJNA666078 | ENA

Human MSI colon cancer study

Project description:Human MSI colon cancer study

| PRJNA700433 | ENA

Cerulenin action on colon cancer cell line

Project description:Showing the anti cancer activity of Cerulenin on colon cancer cell lines. The study shows the mechanismm of apoptosis induction as a result of cerulenin treatment to colon cancer cell lines.

2023-02-05 | PXD023569 | Pride

Differentially expressed miRNAs in colon cancer tissues vs normal colon tissues

Project description:To investigate the role of miRNAs in the progression of colon cancer, we performed comprehensive miRMA microarray analysis on RNA derived from colon cancer tissues and normal colon tissues. We identified a novel set of colon cancer-related miRNAs.

2013-12-16 | GSE53339 | GEO

Colon cancer luminal contents metaproteomics

Project description:Metaproteomics of surgically collected luminal contents from colon cancer patients

2022-05-19 | PXD017467 | Pride

The secretome features associated with the development of re-sistance to vemurafenib in BRAFV600E mutated colon cancer cells

Project description:Patients with metastatic colorectal cancer (mCRC) carrying BRAFV600E mutation have worse response to chemotherapy and poor prognosis. The aim of this study was to conduct for the first time comparative proteomics profiling of the secretome from vemurafenib-sensitive vs. resistant colon cancer cells harboring BRAFV600E mutation in order to identify specific secretory features potentially associated with the development of resistance to vemurafenib. Towards this aim, we employed a label-free quantitative LC-MS/MS analysis. Obtained results pointed to aberrant regulation of DNA replication and the endoplasmic reticulum stress as the major secretome features associated with chemoresistant phenotype. Further studies are required to investigate diagnostic values of these proteins in the clinical setting and to examine their roles in acquired resistance to BRAF inhibition not only in colon cancer but also in other BRAF mutated cancers.

2023-04-29 | PXD039766 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data