Spatial transcriptomics reveals functional compartmentalization of estrogen receptor positive (ER+) breast cancer

ABSTRACT: Intratumor heterogeneity is one of the hallmarks of cancers, including breast cancers. We performed spatial transcriptomics to profile heterogeneous cell populations within ER+ breast cancers as well as to determine their importance for estrogen-dependent tumor growth. Our analysis has revealed the key functional compartments for developing targeted therapeutic strategies against ER+ breast cancers.

ORGANISM(S): Homo sapiens

PROVIDER: GSE214571 | GEO | 2024/02/02

REPOSITORIES: GEO