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Effect of amino acid restriction diet (SARD) combined with anti-PD-L1 on gene expression of cecum orthotopic CT26 tumors.

ABSTRACT: Since both endogenous synthesis in tumor cells and bacterial sulfur reduction activities are sources of H2S in colon cancer microenvironment, in addition to using CBS -/+ mice, we also investigated the roles of reducing H2S through adopting a sulfur amino acid restriction diet (SARD) (0.15% methionine and 0% cystine) on immunotherapy (anti-PD-L1) of colon cancer. Tumor bulk sequencing was performed in cecum orthotopic CT26 tumors collected from IgG and anti-PD-L1 treated mice both receiving normal diet and SARD.

ORGANISM(S): Mus musculus

PROVIDER: GSE214622 | GEO | 2022/10/05

REPOSITORIES: GEO

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