Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

FABP7 drives an inflammatory response in human astrocytes

ABSTRACT: To investigate the effect of FABP7 over-expression in human iPCS-derived astrocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE214628 | GEO | 2024/02/07

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Comprehensive transcriptome analysis of the cochleae of 7-month-old Fabp7 (+/+) and Fabp7 (-/-) mice

Project description:To discover the molecules and signal pathways that are associated with the anti-aging effects of Fabp7 deficiency, transcriptome analyses were conducted using DNA microarray. The ABR thresholds of Fabp7 (+/+) and Fabp7 (-/-) mice were not significantly different at 7 months of age, but it was speculated that important gene expression changes might arise at approximately this stage. Therefore, 7-month-old Fabp7 (+/+) and Fabp7 (-/-) mice were used for transcriptome analyses.

2017-06-23 | GSE83599 | GEO

Profiling the proteomic inflammatory state of human astrocytes using DIA mass spectrometry

Project description:In the present study we used DIA MS to characterize the profile of over 4,000 proteins in immortalized human astrocytes exposed to TNF, IL-1β, and LPS, as well as in primary human astrocytes cocultured with brain endothelial cells and exposed to LPS. For both immortalized and primary astrocytes, DIA MS data were matched against a spectral library generated by merging DDA MS runs from both unfractionated and fractionated cell lysates.

2018-12-10 | PXD009891 | Pride

Transcriptome Analysis of Differentially Expressed Genes in the Wild-type and Fabp7 KO Mouse Inner Ear

Project description:To reveal the function of FABP7 in the inner ear, we evaluated gene expressions between Wild-type and Fabp7 KO mice one day after noise exposure at 10 weeks, using RNA sequencing analysis. The read number was approximately 27–32 million paired-end reads per sample. A total of 24 and 23 genes were identified as upregulated and downregulated differentially expressed genes (DEGs), respectively in Fabp7 KO mice. The upregulation of genes related to nicotinamide-adenine dinucleotide (NADH) dehydrogenase (mt-Nd1, 2, 3, 4, and 6) and a glial high-affinity glutamate transporter (solute carrier family 1, member 2: Slc1a2) and downregulation of genes related to C/D box small nucleolar RNAs were observed in Fabp7 KO mice.

2023-11-22 | GSE241529 | GEO

Identification and analysis of differently expressed genes in liver macrophages from WT and FABP7 KO mice with MC38 metastatic.

Project description:Studies have shown that FABP7 is involved in the occurrence and development of various tumors and can serve as a prognostic marker for tumors. But, the function and molecular mechanism of FABP7 in the tumor microenvironment have not been reported.

2023-09-30 | GSE244156 | GEO

Increased IL-6 and altered inflammatory response in bipolar disorder patient-derived astrocytes

Project description:The goals of this study are to examine responses to inflammation in astrocytes from induced pluripotent stem cells derived from healthy controls and bipolar disorder patients. We examine the transcriptomic inflmmatory signature of generated astrocytes following Il1Beta exposure in BD vs. control Results: BD-patient astrocytes show a unique inflammatory response with differentially regulated genes.

2021-03-19 | GSE157509 | GEO

FABP7 upregulation induces a neurotoxic phenotype in astrocytes.

Project description: Not available

| S-EPMC7573932 | biostudies-literature

Astrocytes' Radiation Response

Project description:Gene expression of X-irradiated primary murine astrocytes Roggan MD, Kronenberg J, Wollert E, Hoffmann S, Nisar H, Konda B, Diegeler S, Liemersdorf C and Hellweg CE (2023) Unraveling astrocyte behavior in the space brain: Radiation response of primary astrocytes. Front. Public Health 11:1063250.

2023-04-12 | GSE215383 | GEO

Exploitable, highly context-specific astrocytes

Project description:To investigate the functional heterogeneity of astrocytes from a defined brain region, we designed 14 experimental manipulations including Huntington's disease models, pathological challenges, ionic and GPCR signaling alterations, and analyzed the transcriptomic profiles of striatal astrocytes. From the analyses, we have identified context-specific changes of striatal astrocytes.

2020-11-17 | GSE153791 | GEO

Exploitable, highly context-specific astrocytes

Project description:To investigate the functional heterogeneity of astrocytes from a defined brain region, we designed 12 experimental manipulations including Huntington's disease models, pathological challenges, ionic and GPCR signaling alterations, and analyzed the transcriptomic profiles of striatal astrocytes. From the analyses, we have identified context-specific changes of striatal astrocytes.

2020-11-17 | GSE143475 | GEO

Exploitable, highly context-specific astrocytes

Project description:To investigate the functional heterogeneity of astrocytes from a defined brain region, we performed single cell RNA-seq of striatal cells from adult mice (8-9 weeks old). From the analyses, we have identified context-specific changes of striatal astrocytes.

2020-10-01 | GSE156628 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data