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Hyperactive PI3K-delta in Th1 and Th2 differentiation

ABSTRACT: We are examining the consequences of activating mutations in PI3K-delta in Th1 vs. Th2 differentiation. Using the house dust mite (HDM) model of allergic airway inflammation, which drives potent Th2 responses in vivo, we have found mice expressing hyper-activated PI3K-delta show impaired Th2 differentiation and instead favor Th1 cell differentiation. We would like to further investigate this aberrant CD4 differentiation profile using scRNA-seq to characterize PI3K-delta regulated aspects of type II immunity.

ORGANISM(S): Mus musculus

PROVIDER: GSE214871 | GEO | 2023/10/04

REPOSITORIES: GEO

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