Transcriptomic profiling of transduced human CD4 T cell expressing different IRF4 mutants

ABSTRACT: A heterozygous IRF4 missense variant located within the interferon activation domain of the encoded IRF4 protein (mutIAD) was identified in three patients from a multigenerational family suffering from a novel autosomal dominant disease predominantly presenting as a hypogammaglobulinemia with recurrent infections. In these experiments we aimed to investigate the effect of this IRF4 mutation on the transcriptome of T lymphocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE214888 | GEO | 2023/03/06

REPOSITORIES: GEO