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Next Generation Sequencing Quantitative Analysis of TEAD Inhibitors in NCI-H226 cells

ABSTRACT: Purpose: The goal of this study is to understand the signaling pathway alteration in NCI-H226 cells treated with TEAD inhibitors. Methods: Mesothelioma cell line NCI-H226 was chosen to be treated with TEAD inhibitors at 1μM for 24 hours. Total RNA was isolated for the analysis. RNA samples were sent to Novogen for library construction, RNA sequencing and raw data process. Conclusions: Our study privides gene expression profiling evidence to validate TEAD inhibitors to block TEAD transcriptional activity in mesothelioma cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE215114 | GEO | 2022/10/15

REPOSITORIES: GEO

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Human malignant mesothelioma NCI-H226 cells treated with TEAD inhibitor K-975 in SCID mice.

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YAP1 exerts its transcriptional control via TEAD mediated activation of enhancers

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A novel irreversible TEAD inhibitor, SWTX-143, blocks the Hippo pathway and causes tumor regression in preclinical mesothelioma models [Invitro]

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2022-02-17 | GSE196672 | GEO

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