Alteration of Microglial Metabolism and Inflammatory Profile Contributes to Neurotoxicity in Frontotemporal Dementia 3

ABSTRACT: Transcriptome profiling of microglia cells carrying a G>C mutation at the last exon (exon six) of the CHMP2B gene linked to frontotemporal dementia (dbSNP: rs63750652) and of the corresponding isogenic controls. Heterozygous and homozygous mutant cells were obtained by precision CRISPR/Cas9 genome editing. All cells were derived from human induced pluripotent stem cells (healthy donor cell line).

ORGANISM(S): Homo sapiens

PROVIDER: GSE215241 | GEO | 2023/08/10

REPOSITORIES: GEO