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Transcriptional patterns of peripheral blood mononuclear cells (PBMCs) in SARS-CoV-2 infected patients with different severity and outcome

ABSTRACT: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological pathogen of coronavirus disease 2019 (COVID-19), a highly contagious disease, spreading quickly and threatening global public health. The symptoms of the disease vary from mild reactions to severe respiratory distress or even fatal outcomes probably due to the different status of innate immunity which is the first line to combat the virus. Here in the study, we unveiled the underlying transcriptional patterns of peripheral blood mononuclear cells (PBMCs) using SARS-CoV-2 infected patients with different severity and outcome. Through systemic analysis, an anti-microbe peptide, α-defensin-1 (DEFA1) was identified to be elevated in both plasma and PBMCs in COVID19 patients, and the function and mechanism is studied.

ORGANISM(S): Homo sapiens

PROVIDER: GSE215262 | GEO | 2023/06/10

REPOSITORIES: GEO

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