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Bazi Bushen extents health span and mitigates epigenetic aging in nature aging mice

ABSTRACT: Bazi Bushen (BZBS), a traditional Chinese medicine, has been proven effective for the treatment in age-related disease models. However, its role in health improvement during the aging process has not yet been explored. In the present study, we investigated the anti-aging effect of BZBS in nature aging mice through Frailty Index assessment, liver DNA methylome, and epigenetic age estimation. Highly differentiated DNA methylation was presented between the young and aged mice, which was mainly concentrated in the promoter region. BZBS treatment protected mice from age-associated DNA methylation changes so that rejuvenated epigenetic age. This result was consistent with the phenotypic observations, including enhanced memory and muscle endurance, less liver lesions, and lower frailty score. Aging-related database screen together with KEGG analysis suggested that methylation-targeted genes upon BZBS treatment were involved in several essential pathways including oxidation-reduction processes, genome stability, MAPK signaling, and inflammation. Up regulation of key effectors in Sirt3-Foxo1 and DNA repair signaling were confirmed. Finally, in silico analysis of the formula revealed anti-aging properties of Renshen, Shengdihuang, Yinyanghuo, and Gouqizi, as well as their potential methylation-regulatory functions. In sum, our work reports the first anti-aging effects of Traditional Chinese Medicine via epigenetic mechanism, thus providing potential life prolonging opportunities.

ORGANISM(S): Mus musculus

PROVIDER: GSE215310 | GEO | 2023/02/27

REPOSITORIES: GEO

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