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Live or heat-killed Lactobacillus rhamnosus aerosolization decreases adenomatous lung cancer development in a mouse carcinogen-induced tumor model

ABSTRACT: One of the responsible factors involved in the progression of pre-malignant lung lesions to lung cancer is the increased immunosuppressive microenvironment of the lung, that is deeply infleunced by the microbiota. In this article, we have investigated if the perturbation of lung microbiota by antibiotics or probiotic aerosol, interferes with lung cancer development in a mouse carcinogen-induced tumor model. Specifically, the effect is mostly observed with aerosol with Lactobacillus Rhamnosus GG that results to impair lung cancer growth by promoting local immunity. This study points out to new and non-invasive strategy to treat individuals at risk of lung cancer.

ORGANISM(S): Mus musculus

PROVIDER: GSE215317 | GEO | 2022/11/29

REPOSITORIES: GEO

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